Abstract
Wrinkles result from repetitive motion in combination with damage from free radicals following exposure to sunlight and pollution. These visual signs of aging can be mitigated with various dermal fillers and botulinum toxins for patients willing to undergo injectable therapies. However, for patients who prefer topical anti-wrinkle treatments over injections, a new technology from NeoStrata may provide a topical benefit. In a preliminary investigation, topical use of the new product increased viable epidermal thickness and built volume in the dermal matrix with the potential for a faster and more potent skin plumping effect than alpha hydroxy acids.
Results
- Penetrates all skin layers to stimulate cellular production of collagen and hyaluronic acid
- Fast volume-building effect in deep skin matrix
- Offers unique ability to target deeper lines and folds
- May serve as an alternative or supplement to injectable anti-wrinkle therapies
Increase at 8 weeks vs baseline
Histology shows positive matrix building effect with Aminofil™
Before and After
Conclusion
The two-step topical line plumper, containing Aminofil™, NeoGlucosamine®, and NeoCitrate™, provides measurable and visible skin plumping benefits. The Active topical line plumper group exhibited significantly greater improvement to clinician-graded targeted lines and wrinkles than the Vehicle control group, as early as week 4 and continuing through week 16. The Active topical line plumper increased skin firmness/elasticity and dermal density.