A Comparative Study of Gluconolactone versus Benzoyl Peroxide in the Treatment of Acne

Author Michelle J. Hunt and Ross StC Barnetson
Year 1992
Publication Australasian Journal of Dermatology


We have performed a double-blind clinical trial on 150 patients to evaluate the efficacy and skin tolerance of the alpha hydroxyl acid gluconolactone 14% in solution in the treatment of mild to moderate acne when compare to its vehicle and 5% benzoyl peroxide lotion. These results of this study showed that both gluconolactone and benzoyl peroxide had a significant effect in improving patients’ acne by reducing the number of lesions.


  • No significant difference was noted between the patients on benzoyl peroxide and gluconolactone. Benzoyl peroxide is a known for the treatment of acne, but many couldn’t use it for long term due to the irritation it may occur.
  • Gluconolactone was effective in reducing the number of superficial inflamed lesions on the skin.
  • Marked improvement in inflamed lesions was observed in the group using 14% gluconolactone.
  • Gluconolactone is gentler to the skin and is suitable for long term use.



There average number of inflamed lesions at each review for the different groups of users